Engineering and Design of Chimeric Antigen Receptors

Engineering and Design of Chimeric Antigen Receptors

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T cells engineered with chimeric antigen receptors (CARs) have emerged as a potent new class of therapeutics for cancer, based on their valhalla axys remarkable potency in blood cancers.Since the first clinical reports of their efficacy emerged 7 years ago, investigators have focused on the mechanisms and properties that make CARs effective or toxic, and their effects Sneakers for Men - Grey - Canvas Mesh Athletic Running Shoes on T cell biology.Novel CAR designs coupled with improvements in gene transfer technology, incorporating advances in gene editing, have the potential to increase access to engineered cell therapies, as well as improve their potency in solid tumors.Keywords: CAR T cells, immunotherapy, chimeric antigen receptors, cancer.